EC Number   |
General Information |
Reference |
|---|
    2.7.1.82 | evolution |
human ethanolamine kinase exists as three isoforms: EK1, EK2alpha and EK2beta, encoded by two separate genes; ek1, which produces the ek1 transcript variant 1, and ek2, which undergoes alternative splicing to produce ek2alpha (NCBI reference: NM_018208.2) and ek2beta (GenBank reference: AK001623.1) transcript variants. ek2alpha and ek2beta are respectively translated into EK2alpha and EK2beta |
739083 |
| 2.7.1.82 | evolution |
the enzmye belongs to the choline/ethanolamine kinase (CEK) family catalyzing the initial steps of phospholipid biosynthesis |
739295 |
| 2.7.1.82 | malfunction |
knocking out of CEK4 caused an embryo-lethal phenotype with defective embryo development, which is complemented by transformation of genomic CEK4. Overexpression of enzyme CEK4 in wild-type Arabidopsis thaliana increases the levels of phosphatidylcholine in seedlings and mature siliques and of major membrane lipids in seedlings and triacylglycerol in mature siliques |
739295 |
| 2.7.1.82 | malfunction |
somatic enzyme mutations targeted to two contiguous amino acids in the ETNK1 kinase domain are involved in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia, phenotypes, overview |
737928 |
| 2.7.1.82 | malfunction |
the gene Treki deletion mutant strain is less sensitive to cell wall stressors calcofluor white and Congo red and releases fewer protoplasts during cell wall digestion than the parent strain QM9414. The expression levels of five genes that encode chitin synthases are drastically increased in the Treki1 mutant, the chitin content is also increased in the null mutant of Treki1 comparing to the parent strain, and the Treki1 mutant exhibits defects in radial growth, conidiation and the accumulation of ethanolamine, phenotype overview |
-, 738268 |
| 2.7.1.82 | metabolism |
a key enzyme in cellular phospholipid synthesis |
739440 |
| 2.7.1.82 | metabolism |
catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway |
-, 738268 |
| 2.7.1.82 | metabolism |
choline kinase and ethanolamine kinase are enzymes that initiate the first step in the Kennedy pathway, resulting in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine. Expression profiling of ethanolamine kinase in MCF-7, HCT-116 and Hep-G2 cells, and the transcriptional regulation by epigenetic modification |
739083 |
| 2.7.1.82 | metabolism |
the enzyme catalyzes the initial steps of phospholipid biosynthesis |
739295 |
| 2.7.1.82 | physiological function |
enzyme CEK4 may be the plasma membrane-localized isoform of the CEK family involved in the rate-limiting step of phosphatidylcholine biosynthesis and appears to be required for embryo development in Arabidopsis thaliana |
739295 |
