EC Number   |
General Information |
Reference |
|---|
   2.7.1.59 | evolution |
the enzyme is a member of the BcrAD/BadFGlike ATPase family |
722533 |
| 2.7.1.59 | malfunction |
enzyme knockdown delays cell division |
759773 |
| 2.7.1.59 | malfunction |
enzyme knockdown results in dendrite degeneration |
739070 |
| 2.7.1.59 | malfunction |
the homozygous hxk1 mutant H8-1-103 is constitutively filamentous and hyperfilamentous under filamentation inducing conditions |
723600 |
| 2.7.1.59 | metabolism |
HXK1 acts as both positive and negative regulator of transcription of genes involved in maintaining cellular homeostasis, regulatory mechanism involved in filamentation repression, overview |
723600 |
| 2.7.1.59 | physiological function |
enzyme-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown and metaphase MT-KT attachment during eukaryotic cell division |
759773 |
| 2.7.1.59 | physiological function |
HXK1 plays a crucial role in morphogenesis, GlcNAc signaling/metabolic genes expression and maintenance of various cellular functions in Candida albicans, Hxk1 is involved in the cell wall synthesis and in repression of hyphal specific genes in addition to metabolic genes. Its regulation of filamentation and GlcNAc metabolism is independent of the known classical regulators like EFG1, CPH1, RAS1, TPK2 or TUP1, regulatory mechanism involved in filamentation repression, overview |
723600 |
| 2.7.1.59 | physiological function |
the enzyme interacts with DYNLRB1 in primary hippocampal neurons |
738177 |
| 2.7.1.59 | physiological function |
the enzyme promotes dynein functionality by interacting with dynein light chain roadblock type 1 and efficiently suppressing mutant huntingtin Q74 and alpha-synuclein A53T aggregation in mouse brain cells |
759020 |
| 2.7.1.59 | physiological function |
the enzyme promotes the axonal growth of developing neurons |
739073 |
