EC Number   |
General Information |
Reference |
|---|
    2.7.1.39 | malfunction |
deletion mutants show homoserine-mediated lethality |
-, 722151 |
| 2.7.1.39 | malfunction |
homoserine kinase deletion mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation |
722152 |
| 2.7.1.39 | malfunction |
homoserine kinase deletion mutants are extremely serum sensitive and hypersensitive to DNA-damaging agents |
722152 |
| 2.7.1.39 | malfunction |
mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and Fusarium graminearum which cause Fusarium Ear Blight disease on small grain cereals |
737948 |
| 2.7.1.39 | metabolism |
downy mildew resistance is mediated by mutation of homoserine kinase: homoserine accumulation in the chloroplast triggers a novel form of downy mildew resistance |
706213 |
| 2.7.1.39 | more |
a conserved active-site alanine residue, A20, in CThrB (CglThrB) is important for differential interactions with L-threonine and L-homoserine |
-, 758579 |
| 2.7.1.39 | more |
molecular modeling and simulation study of homoserine kinase (HSK) as an effective leishmanial drug target. Two MD simulations are performed on HSK enzyme without substrate (for reference), and on the enzyme in complex with the substrate, prosthetic group, and the magnesium ion using the NAMD program with CHARMM all-atom force field. The topology and parameters for the ligands used in this study are obtained from the MATCH web server. Virtual screening of a compound library and docking study. Homology modeling using several templates, overview. The active site of HSK mainly constitutes of two aspartates, two asparagine residues, and an arginine. All these residues are found to be optimally placed in the predicted model (Asn23, Asp29, Asp144, Asn145, and Arg241). Substrate recognition and structure-function analysis |
759641 |
