Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 8 of 8
download as CSV
download all results as CSV
EC Number General Information Commentary Reference
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177evolution Rhodobacterales lack pduX, instead they have the non-orthologous bluE gene that encodes an enzyme that, unlike PduX, is specific for L-Thr and cannot use L-Ser. Phylogenetic analysis. The RsBluE enzyme is found to be restricted to a subclass of Rhodobacterales with genetic attributes that indicate they have a strong preference for AdoCbl. That is to say, these Rhodobacter species prefer and synthesize only a cobamide (Cba) with DMB as the lower ligand base and AP-P as the nucleotide linker, Coalpha-(alpha-5,6-dimethylbenzimidazolyl-Cobeta-adenosylcobamide) (a.k.a. adenosylcobalamin, AdoCbl, coenzyme B12, CoB12). Cells with incomplete AdoCbl production have a pigmentation phenotype -, 761921
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177evolution the CobD protein from Methanosarcina mazei differs from other CobD homologues by the presence of a 111-amino acid cysteine-rich extended C-terminus (MmCobD386-497) annotated as a putative metal-binding domain or zinc finger protein, but it actually is a ferroprotein. This C-terminal domain is sometimes encoded as an independent protein and other times fused to other Cba biosynthetic proteins (e.g. CbiZ, CbiA, CbiH, or BtuC) 760602
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177malfunction inactivation of gene bluE in Rhodobacter sphaeroides causes AdoCbl-dependent growth phenotypes, DELTAbluE strains fail to grow compared to bluE+ controls. A blush phenotype for the DELTAbluE strain is observed and the amount of light-harvesting complex 1 (LH1 B875) reaction center pigments of this strain are reduced relative to those in cultures of the DELTAbluE strain growing in the presence of AdoCbl after measurements are normalized for the cell density of each culture. The blush phenotype is also corrected by the addition of CNCbl to the medium -, 761921
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177malfunction there is a 2600fold decrease in catalytic efficiency (kcat/Km) when the C-terminus is removed, or a 1200fold decrease when the enzyme is purified normoxically 760602
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177metabolism enzyme BluE is the L-Thr kinase involved in AdoCbl biosynthesis in Rhodobacterales -, 761921
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177metabolism involved in the biosynthesis of adenosylcobalamin 717877, 717878
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177more MmCobD displays redox-sensitivity 760602
Show all pathways known for 2.7.1.177Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.177physiological function MmCobD is a bifunctional enzyme with L-threonine (L-Thr) kinase (PduX, EC 2.7.1.177) and pyridoxal 5'-phosphate (PLP)-dependent L-threonine phosphate (L-Thr-P) decarboxylase activities needed to synthesize the (R)-1-amino-propan-2-ol O-phosphate (a.k.a. (R)-1-amino-2-propanol-O-2-phosphate, AP-P) moiety of cobalamine (Cbl) -, 760602
Results 1 - 8 of 8
download as CSV
download all results as CSV