EC Number |
General Information |
Reference |
---|
2.7.1.149 | evolution |
PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction |
721247 |
2.7.1.149 | evolution |
two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell |
723270 |
2.7.1.149 | evolution |
two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell |
-, 723270 |
2.7.1.149 | malfunction |
enzyme depletion enhances the spindle pole accumulation of mitotic centromere-associated kinesin, a microtubule-depolymerizing kinesin, and results in a less stable spindle pole-associated microtubule |
759023 |
2.7.1.149 | malfunction |
enzyme knockdown leads to severe morphological abnormalities, including midbody winding defects at 48 h post-fertilization |
738389 |
2.7.1.149 | malfunction |
enzyme-deficient animals show enhanced insulin signaling-dependent phenotypes and are resistant to the metabolic consequences of a high-sugar diet |
759027 |
2.7.1.149 | malfunction |
flies lacking the enzyme show mislocalization of rhodopsin 1 on expanded endomembranes within the cell body. Enzyme loss is associated with increased clathrin-mediated endocytosis and an enlarged Rab5-positive compartment in cultured Drosophila cells |
759534 |
2.7.1.149 | malfunction |
isoform PI4Kgamma5 deficiency results in the serrated leaves and accelerated cell division at leaf margin due to the increased auxin level |
739399 |
2.7.1.149 | malfunction |
long-Term loss of isoform PI5P4Kalpha by gene disruption results in compromised Akt phosphorylation |
760061 |
2.7.1.149 | malfunction |
loss-of-function mutants in PIP4K show reduced body weight and prolonged larval development |
739535 |