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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.6.1.64metabolism glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. Transcriptional regulators TAZ and YAP (TAZ/YAP) promote glutamine dependence in breast cancer cells and activate the expression of glutamine-utilizing transaminases to support cell growth. TAZ/YAP induce glutamic-oxaloacetic transaminase (GOT1) and phosphoserine aminotransferase (PSAT1, EC 2.6.1.52) expression. Transcriptional regulators TAZ/YAP activity positively correlates with transaminase expression in breast cancer patients, while transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner. Thus, transamination is a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer. TAZ/YAP promote anaplerotic entry of glutamine through transamination 759123
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