EC Number   |
General Information |
Reference |
|---|
    2.6.1.18 | evolution |
aminotransferase enzymes function via a bimolecular double displacement ping-pong mechanism where an amino acid usually serves as the amino donor and an alpha-keto acid serves as the amino acceptor. Aminotransferases are ubiquitous in the three domains of life and are involved in a variety of metabolic pathways including amino acid metabolism, nitrogen assimilation, gluconeogenesis, responses to a number of biotic/abiotic stresses, and among other pathways. The aminotransferase gene family in the model plant Arabidopsis thaliana consists of 44 genes, eight of which are suggested to be alanine aminotransferases. One of the putative alanine aminotransferases genes, At3g08860, is attributed the function of alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other beta-alanine aminotransferases in plants |
-, 759951 |
| 2.6.1.18 | evolution |
fold type I and IV of PLP-dependent omega-transaminases (omega-TAs) show (R)- and (S)-selectivity, respectively |
759802 |
| 2.6.1.18 | metabolism |
the expression of At3g08860 is highly coordinated with the genes of the uracil degradation pathway leading to the non-proteinogenic amino acid beta-alanine |
-, 759951 |
| 2.6.1.18 | more |
structural analysis and homology modeling of the At3g08860-encoded enzyme |
-, 759951 |
| 2.6.1.18 | more |
structure-function analysis, overview |
759057 |
| 2.6.1.18 | more |
the reaction mechanism of transaminase-catalyzed reactions consists of two half-reactions and is described as a ping-pong-bi-bi mechanism. The widespread alpha-TAs are limited to alpha-amino acids, containing the amino or keto group in the alpha position to a carboxylic function. In contrast, omega-TAs are able to transfer amino groups in different positions to the carboxylic moiety or even in the absence of carboxylic functions |
759802 |
| 2.6.1.18 | physiological function |
the enzyme produces beta-alanine, which is an osmoprotectant in plants |
-, 759951 |
