EC Number   |
General Information |
Reference |
|---|
   2.5.1.91 | evolution |
the enzyme contains six conserved motifs (from I to V), i.e., motif I (GKxxR), motif II (DDxxD(x)4RRG), motif III (GExxQ), motif IV (Y(x)6KT), motif V (FQLxDDxxD) and motif VI (K(x)4DxxxGxxTxPxL), occurring in all DPPS-1s examined, including insect, vertebrate, yeast and plant DPPS-1s, and bacterial DPPSs |
737596 |
| 2.5.1.91 | malfunction |
construction of an Schizosaccharomyces pombe dps-deficient strain. This disruptant is not able to synthesize ubiquinone and has no detectable decaprenyl diphosphate synthase activity. The Sschizosaccharomyces pombe dps-deficient strain could not grow on either rich medium supplemented with glycerol or on minimal medium supplemented with glucose. The dps-deficient strain requires cysteine or glutathione for full growth on the minimal medium. In addition, the dps-deficient strain is more sensitive to H2O2 and Cu2+ than the wild type |
704340 |
| 2.5.1.91 | malfunction |
pathogenic mutations in PDSS2 (PDSS2 encodes the second subunit of decaprenyl diphosphate synthase) causing primary CoQ10 deficiency in an infant with fatal Leigh syndrome and nephrotic syndrome |
701606 |
| 2.5.1.91 | malfunction |
the deletion mutant of dlp1 lacks the enzymatic activity of decaprenyl diphosphate synthase, does not produce ubiquinone-10 and has the typical ubiquinone-deficient Schizosaccharomyces pombe phenotypes, namely hypersensitivity to hydrogen peroxide, the need for antioxidants for growth on minimal medium and an elevated production of H2S. Both the dps1 and dlp1 mutants can generate ubiquinone when they are transformed with a bacterial decaprenyl diphosphate synthase, which functions in its host as a homodimer |
703537 |
| 2.5.1.91 | physiological function |
an dps1 disruptant strain is not able to synthesize ubiquinone and has no detectable decaprenyl diphosphate synthase activity. The dps-deficient strain cannot grow on either rich medium supplemented with glycerol or on minimal medium supplemented with glucose. The dps-deficient strain requires cysteine or glutathione for full growth on the minimal medium. The dps-deficient strain is more sensitive to H2O2 and Cu2+ than the wild type |
704340 |
| 2.5.1.91 | physiological function |
both genes DPS1 and DLP1 are required for decaprenyl diphosphate synthase activity. The deletion mutant of dlp1 lacks the enzymatic activity of decaprenyl diphosphate synthase, does not produce ubiquinone-10 and has the typical ubiquinone-deficient Schizosaccharomyces pombe phenotypes, namely hypersensitivity to hydrogen peroxide, the need for antioxidants for growth on minimal medium and an elevated production of H2S. Both the dps1 and dlp1 mutants can generate ubiquinone when they are transformed with a bacterial decaprenyl diphosphate synthase, which functions in its host as a homodimer |
703537 |
| 2.5.1.91 | physiological function |
the enzyme catalyzes the consecutive condensation of isopentenyl diphosphate with allylic diphosphates to produce decaprenyl diphosphate, which is used for the side chain of ubiquinone Q10 |
703533 |
| 2.5.1.91 | physiological function |
the insect long-chain prenyl diphosphate synthase is responsible for the biosynthesis of the side-chain of ubiquinone-10, UQ-10, in Aphis gossypii |
737596 |
