EC Number   |
General Information |
Reference |
|---|
    2.5.1.90 | evolution |
octaprenyl diphosphate synthase, OPP, belongs to the trans-prenyltransferase class of protein |
739617 |
| 2.5.1.90 | evolution |
the enzyme belongs to the E-type prenyltransferase family |
737369 |
| 2.5.1.90 | malfunction |
it is impossible to obtain an ispB deletion mutant unless the ispB gene or its homolog is supplied on a plasmid. The ispB gene is essential for the normal growth of Escherichia coli |
704255 |
| 2.5.1.90 | metabolism |
octaprenyl pyrophosphate synthase catalyzes the chain elongation of farnesyl pyrophosphate via consecutive condensation reactions with five molecules of isopentenyl pyrophosphate to generate all-trans C40-octaprenyl pyrophosphate. The polymer forms the side chain of ubiquinone that is involved in electron transport system to produce ATP |
-, 747162 |
| 2.5.1.90 | more |
enzyme homology modeling, overview. (2E,6E)-Farnesyl diphosphate is bound to the first DDXXD motif, and isopentenyl diphosphate is bound to several cationic residues (e.g. Arg, Lys, and His) via diphosphate, but not to the second DDXXD motif. The enzyme contains an elongated tunnel-shaped crevice as the active site to accommodate its reactants and product |
739617 |
| 2.5.1.90 | more |
enzyme structure modelling using the structure of Rhodobacter capsulatus decaprenyl diphosphate synthase, PDB ID 3mzv, as a template model |
737369 |
| 2.5.1.90 | physiological function |
gene product of gbs1789 is involved in the biosynthesis of long-chain demethylmenaquinones. A gbs1789 mutant cannot respire in the presence of heme and dihydroxy-2-naphthoic acid. Isoprenoid side chains from Group B Streptococcus demethylmenaquinones are produced by the protein encoded by the gbs1783 gene, since this gene can complement an Escherichia coli ispB mutant defective for isoprenoids chain synthesis |
-, 739093 |
| 2.5.1.90 | physiological function |
octaprenyl diphosphate synthase is responsible for the synthesis of the side chain of isoprenoid quinones |
704255 |
| 2.5.1.90 | physiological function |
the chromosomal ispB disrupted mutant cannot be isolated unless the ispB gene or its homolog is supplied on a plasmid. The chromosomal ispB disruptants that harbor plasmids carrying the ispB homologs from Haemophilus influenzae and Synechocystis sp. strain PCC6803 produce mainly ubiquinone 7 and ubiquinone 9, respectively |
704255 |
| 2.5.1.90 | physiological function |
the enzyme catalyzes consecutive condensation reactions of farnesyl diphosphate with isopentenyl diphosphate to generate octaprenyl diphosphate, which constitutes the side chain of bacterial ubiquinone or menaquinone |
704411 |
