EC Number   |
General Information |
Reference |
|---|
    2.5.1.65 | metabolism |
two biosynthetic routes to L-cysteine, each with its own specific cysteine synthase (CysK1 and CysM), are described in Mycobacterium tuberculosis, and a third putative sulfhydrylase in this pathogen, CysK2, is an S-sulfocysteine synthase, utilizing O-phosphoserine (OPS) and thiosulfate as substrates. Mycobacterial CysK2 thus provides a third metabolic route to cysteine, either directly using sulfide as donor or indirectly via S-sulfocysteine, cysteine synthasis pathways overview |
-, 738534 |
| 2.5.1.65 | more |
Intramolecular electrostatic interaction of enzyme OPSS, overview |
-, 737868 |
| 2.5.1.65 | more |
three-dimensional structure analysis of enzyme ApOPSS in complex with aminoacrylate intermediate formed from pyridoxal 5'-phosphate with O-phospho-L-serine or the enzyme in complex with L-cysteine, and structure comparisons, molecular docking simulation using the structure of PDB ID 3VSA as the wild-type enzyme ApOPSS, overview |
-, 738193 |
| 2.5.1.65 | physiological function |
the enzyme synthesizes S-sulfocysteine, the can also act as a signaling molecule triggering additional responses in redox defense in the pathogen upon exposure to reactive oxygen species during dormancy |
-, 738534 |
