EC Number   |
General Information |
Reference |
|---|
    2.5.1.22 | drug target |
spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Combined inhibition of spermine synthase and MYC signaling may be an effective therapy for colorectal cancer |
759826 |
| 2.5.1.22 | malfunction |
cells derived from patients with Snyder-Robinson syndrome, a rare X-linked recessive human disease caused by SMS gene mutations that greatly reduce the content of spermine synthase, show an increase in decarboxylated S-adenosylmethionine |
721528 |
| 2.5.1.22 | malfunction |
in Gy mice, which lack spermine synthase activity, the content of dcAdoMet is significantly increased by 10-30fold in liver, brain and kidney and by 150fold in heart. Transgenic expression of spermine synthase in the Gy mice reverses all of the increases in dcAdoMet content and AdoMetDC, phenotypes, overview |
721528 |
| 2.5.1.22 | malfunction |
mutations in the spermine synthase gene are associated with Snyder Robinson mental retardation syndrome |
758946 |
| 2.5.1.22 | malfunction |
OsSPMS1 knockout mutant show an increase in grain yield per plant in a high-yield variety, Suken118 suggesting that OsSPMS1 is an important target for yield enhancement in rice |
759983 |
| 2.5.1.22 | malfunction |
SMS single missense mutations cause the Snyder-Robinson Syndrome, SRS. Concerning mutability depending on structural micro-environment and involvement in the function and structural integrity of the SMS, the I150 site does not tolerate any mutation, while V132, despite its key position at the interface of SMS dimer, is quite mutable. The G56 site is still quite sensitive to charge residue replacement |
723531 |
| 2.5.1.22 | malfunction |
spermine and thermospermine synthesis mutants accumulate more Na+ and show decreased survival under salt stress compared to wild-type plants |
723483 |
| 2.5.1.22 | metabolism |
spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression |
759826 |
| 2.5.1.22 | metabolism |
the enzyme is critical for maintaining the balance of spermine/spermidine in the cell |
759684 |
| 2.5.1.22 | physiological function |
inverse relationship between the amount of spermine synthase protein and the content of decarboxylated S-adenosylmethionine. In mice lacking spermine synthase occurs a large increase in decarboxylated S-adenosylmethionine, dcAdoMet, overexpression of human spermine synthase reduces the amount of this nucleoside, Content of AdoMet and dcAdoMet in cultured lymphoblasts from control and Snyder-Robinson syndrome patients |
721528 |
