EC Number |
General Information |
Reference |
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2.5.1.108 | malfunction |
loss of Dph4 results in lack of diphthamide modification of eEF2 and resistance to diphtheria toxin. Dph4 mutant mice are growth retarded and have a specific digit defect with one or more additional preaxial digits |
725594 |
2.5.1.108 | malfunction |
mutation in DPH2 blocks diphthamide biosynthesis |
718109 |
2.5.1.108 | physiological function |
diphthamide biosynthesis proteins Dph1 and Dph2 interact and the first step of diphthamide formation on eukaryotic translation elongation factor eEF2 requires a complex formed in vivo between Dph1, Dph2 and Dph3 |
739730 |
2.5.1.108 | physiological function |
first step of diphthamide biosynthesis, a unique posttranslational modification on a histidine residue of translational elongation factor 2 |
723158 |
2.5.1.108 | physiological function |
required for diphthamide biosynthesis |
718109 |
2.5.1.108 | physiological function |
the enzyme is involved in diphthamide biosynthesis |
718109, 723263 |