EC Number   |
General Information |
Reference |
|---|
    2.5.1.1 | drug target |
the enzyme is a target for treating bone resorption diseases and some cancers |
759609 |
| 2.5.1.1 | evolution |
Artemisia tridentata chrysanthemyl diphosphate synthase is an example of an enzyme that has evolved recently from a highly specialized parent. The origins of farnesyl diphosphate synthase date back to the very beginning of cellular life, and the enzyme has perfected its ability to catalyze chain-elongation. In contrast, Artemisia tridentata chrysanthemyl diphosphate synthase has recently evolved from Artemisia tridentata diphosphate synthase, presumably by gene duplication and random mutagenesis but is still a promiscuous inefficient catalyst in comparison with farnesyl diphosphate synthase |
759401 |
| 2.5.1.1 | metabolism |
farnesyl diphosphate synthase is a key enzyme responsible for the supply of isoprenoid precursors for several essential metabolites, including sterols, dolichols and ubiquinone |
759205 |
| 2.5.1.1 | metabolism |
produces geranylgeranyl diphosphate for the synthesis of carotenoids in the chloroplast |
759731 |
| 2.5.1.1 | metabolism |
the enzyme is able to provide the geranyl diphosphate precursor required for efficient production of both double bond isomers of farnesyl diphosphate in Mycobacterium tuberculosis |
-, 722274 |
| 2.5.1.1 | metabolism |
the enzyme plays a key role in the biosynthesis of the morphogenetic and gonadotropic juvenile hormone |
759334 |
| 2.5.1.1 | metabolism |
under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis |
759937 |
| 2.5.1.1 | physiological function |
the enzyme is involved in the biosynthesis of the monoterpenoid precursors needed for formation of the defensive compound chrysomelidial |
723664 |
| 2.5.1.1 | physiological function |
under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis |
759937 |
