EC Number   |
General Information |
Reference |
|---|
   2.4.2.38 | malfunction |
expression of the tomato beta1,2-xylosyltransferase is down-regulated by RNA interference in transgenic tomato plants. On the basis of IgE immunoblotting assays XylT-RNAi tomato fruits reveal a patient-specific reduction in IgE reactivity. Patients with tomato allergy have reduced mean wheal diameters in skin prick tests, demonstrating a reduced allergenic potential of XylT-RNAi tomato fruits in vivo |
722313 |
| 2.4.2.38 | malfunction |
loss of XT1 does not affect in vitro growth of mutant cells or general morphology of their capsules. The two main capsule polysaccharides, glucuronoxylomannan and galactoxylomannan, both are missing beta1,2-xylose residues. Deletion of XT1 leads to attenuation of cryptococcal growth in a mouse model of infection |
693051 |
| 2.4.2.38 | metabolism |
the enzyme catalyzes the initial step of glycosaminoglycan biosynthesis |
735595 |
| 2.4.2.38 | physiological function |
Xt1p has a defined role in capsule biosynthesis |
693051 |
