EC Number   |
General Information |
Reference |
|---|
    2.4.2.19 | metabolism |
key enzyme in the de novo nicotinamide adenine dinucleotide synthesis pathway |
758726 |
| 2.4.2.19 | physiological function |
interacts with active-caspase-3, depletion of quinolinate phosphoribosyltransferase protein increases intracellular caspase-3 activity, quinolinate phosphoribosyltransferase-depleted cells are highly sensitive to spontaneous cell death, quinolinate phosphoribosyltransferase protein prevents spontaneous cell death through inhibition of overproduction of active-caspase-3, identified as a caspase-3 binding protein, not a substrate for caspase-3 |
721705 |
| 2.4.2.19 | physiological function |
overexpression and purification of the mutant enzymes produce 200-250 mg of protein/6 liter of culture similar to that of the wild-type enzyme |
702359 |
| 2.4.2.19 | physiological function |
the enzyme inhibits hepatitis C virus replication via reduction of cellular lipogenesis |
760157 |
| 2.4.2.19 | physiological function |
the enzyme is essential for maintaining the homeostasis of quinolinic acid in the brain |
737258 |
| 2.4.2.19 | physiological function |
the enzyme is involved in the biosynthetic pathway of the alkaloids nicotine and anabasine and also affects plant growth and development |
759914 |
| 2.4.2.19 | physiological function |
the enzyme with anti-apoptotic properties is a direct target gene of Wilms' tumor gene 1 in leukemic cells. Enzyme overexpression in K-562 leukemic cells increases resistance to imatinib |
758726 |
