EC Number   |
General Information |
Reference |
|---|
    2.4.1.83 | evolution |
PfDPMS is a membrane enzymes of the GT2 family. All known bona fide DPMSs use GDP-Man as donor substrate. Proposed model of substrate binding and product release |
-, 757762 |
| 2.4.1.83 | malfunction |
failure to produce or utilize dolichyl mannosyl phosphate compromises organism viability |
-, 757762 |
| 2.4.1.83 | malfunction |
loss-of-function mutations and RNA interference-mediated reduction of DPMS1 expression in Arabidopsis causes a wrinkled seed coat phenotype and most remarkably enhanced hypersensitivity to ammonium that is manifested by extensive chlorosis and a strong reduction of root growth |
723410 |
| 2.4.1.83 | metabolism |
dolichyl phosphate mannose synthase is a key enzyme in the O-glycosylation pathway |
723228 |
| 2.4.1.83 | metabolism |
the enzyme is involved in dolichylphosphate mannose biosynthesis |
-, 757762 |
| 2.4.1.83 | more |
structure-function analysis, and structural comparison with related enzymes, detailed overview. The IF helices IFH1 and IFH2 are important for activity |
-, 757762 |
| 2.4.1.83 | physiological function |
elevated activity of overexpressed Saccharomyces cerevisiae dolichyl phosphate mannose synthase enhances biocontrol abilities of Trichoderma atroviride |
723228 |
| 2.4.1.83 | physiological function |
high level of expression of (GlcNAc-beta-(1,4)-GlcNAc) 1-4-beta-GlcNAc-NeuAc glycans on the external surface of the capillary endothelial cells overexpressing DPMS. Increased cellular proliferation and accelerated healing of the wound induced by mechanical stress of the DPMS-overexpressing clone unequivocally supports a role of DPMS in angiogenesis |
702004 |
| 2.4.1.83 | physiological function |
overexpression of DPMS accelerates angiogenesis, a higher rate of cellular proliferation in DPMS overexpressing cells compared to the pEGFP-N1 vector and the parental cells |
703922 |
| 2.4.1.83 | physiological function |
overexpression of DPMS1 in Arabidopsis thaliana results in disorganized stem morphology and vascular bundle arrangements, wrinkled seed coat, and constitutive ER stress response |
723410 |
