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EC Number General Information Commentary Reference
Show all pathways known for 2.4.1.277Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.277physiological function coexpression of glycosyltransferase DesVII and its auxiliary partner DesVIII in a Saccharopolyspora erythraea EryBV deletion mutant leads to an increased erythromycin A yield by 15% in comparison to Saccharopolyspora erythraea wild-type. DesVII/DesVIII replaced EryCIII to upload D-desosamine to C5 position of 3-O-mycarosyl erythronolide B and also in vivo attache L-mycarose, not D-desosamine to C3 position of erythronolide B with a higher activity than EryBV. Expression of DesVII in EryCIII and EryBV-CIII mutant strains partially restores the erythromycin A production, however, no erythromycin A is detected while DesVII is expressed in the EryBV mutant strain 735516
Show all pathways known for 2.4.1.277Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.277physiological function the enzyme is involved in biosynthesis of macrolide antibiotics 715244
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