EC Number   |
General Information |
Reference |
|---|
   2.4.1.147 | malfunction |
disruption of the C3GnT gene reduces levels of colon-specific Muc2 protein. Nod agonists fail to enhance goblet cell numbers and Muc2 production in C3GnT deficient mice |
-, 736236 |
| 2.4.1.147 | malfunction |
mice lacking intestinal core 1-derived O-glycans (IEC C1galt1-/-) develop spontaneous colitis primarily in the distal colon, whereas mice lacking both intestinal core 1- and core 3-derived O-glycans (DKO) develop spontaneous colitis in both distal and proximal colon. DKO mice show an early onset and more severe colitis than IEC C1galt1-/- mice. Antibiotic treatment restores the mucus layer and attenuates colitis in DKO mice. Mucins from DKO mice are more susceptible to proteolysis than wild-type mucins. C3GnT-/- mice exhibits no colitis phenotype without challenge. Analysis of colitis development in wild-type and mutant mice, overview. Loss of both core 1- and core 3-derived O-glycans affects mucus layer structure and colitis susceptibility throughout the colon. Antibiotic (NMVA) treatment improves mucus layer and reduces severity of colitis in DKO mice. Colitis is driven by bacterial-mucosal interactions following mucus barrier breach |
759814 |
| 2.4.1.147 | metabolism |
core 1- and 3-derived O-glycans collectively contribute to the mucus barrier by protecting it from bacterial protease degradation |
759814 |
| 2.4.1.147 | metabolism |
O-glycan biosynthesis pathways and proposed O-glycan structures of selected glycosyltransferases, overview. GalNAc alpha1-Ser/Thr is converted by C3 beta3GnT6 to core 3 O-glycans. Regulation of O-glycan biosynthesis, overview |
736540 |
| 2.4.1.147 | physiological function |
core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT), which controls the biosynthesis of core 3 O-glycans, is expressed mainly in the intestine and salivary glands |
759814 |
| 2.4.1.147 | physiological function |
in humans, the core 3 structure (GlcNAcbeta1-3GalNAcalpha1-O-Ser/Thr) has been found in mucins from specific tissues such as the stomach, small intestine, and colon, and the human gene (B3GNT6) encoding the core 3 synthase (uridine diphosphate [UDP]-GlcNAc:betaGal beta1,3-N-acetylglucosaminyltransferase, beta3Gn-T6) is involved in core 3 synthesis |
758840 |
| 2.4.1.147 | physiological function |
the enzyme is an important enzyme in mucin and core 3-derived O-glycans synthesis. Role of Nod proteins in regulation of intestinal goblet cell response in naive mice and mice infected with the enteric parasite Trichuris muris, overview. Nod proteins are important in postive enzyme regulation, treatment with Nod agonists upregulates C3GnT expression both in vivo and in vitro, overview |
-, 736236 |
