EC Number   |
General Information |
Reference |
|---|
   2.3.2.20 | evolution |
CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold. The XYP and NYH motifs correspond to two structural solutions to facilitate the reactivity of the catalytic serine residue. The CDPS from Fluoribacter dumoffii belongs to the XYP subfamily |
759679 |
| 2.3.2.20 | evolution |
CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold. The XYP and NYH motifs correspond to two structural solutions to facilitate the reactivity of the catalytic serine residue. The CDPS from Nocardia brasiliensis belongs to the XYP subfamily |
-, 759679 |
| 2.3.2.20 | evolution |
CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold. The XYP and NYH motifs correspond to two structural solutions to facilitate the reactivity of the catalytic serine residue. The CDPS from Rickettsiella grylli belongs to the XYP subfamily |
-, 759679 |
| 2.3.2.20 | evolution |
CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold. The XYP and NYH motifs correspond to two structural solutions to facilitate the reactivity of the catalytic serine residue. The CDPS from Streptomyces noursei belongs to the NYH subfamily |
759679 |
| 2.3.2.20 | evolution |
methyltransferase homologues are commonly encoded within putative CDPS gene clusters, yet methyltransferases from only two of these clusters have been characterized to date. One leads to methylated members of the nocazine/XR334 (e.g. XR334) family and the other catalyzes DKP N-methylation of cyclo(L-tryptophanyl-L-tryptophanyl) (cWW) to yield dimethyl-cyclo-Trp-Trp (Me2-cWW) |
-, 759890 |
| 2.3.2.20 | evolution |
the entire family of CDPSs can be classified into two subfamilies, so called NYH and XYP, characterized by the presence of specific sequence signatures at positions N40, Y202, and H203. The residues, N40 and H203 are suggested to play a role in the stabilization of other residues in the catalytic center and are not conserved among the CDPS family, but are important for the function of AlbC |
760169 |
| 2.3.2.20 | metabolism |
comparison of different CDPS-containing biosynthetic pathways, enzyme AlbC is involved in the albonoursin biosynthetic pathway, overview. Assembly of the cyclo-Phe-Leu precursor of albonoursin is catalyzed by CDPS AlbC, which also yields a variety of other cyclic dipeptides as minor products |
759890 |
| 2.3.2.20 | metabolism |
comparison of different CDPS-containing biosynthetic pathways, enzyme BcmA is involved in the bicyclomycin biosynthetic pathway, overview. The proposed bicyclomycin (i.e. (1S,6R)-6-hydroxy-5-methylidene-1-[(2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione) biosynthetic pathway features a cascade of oxidative transformations |
759890 |
| 2.3.2.20 | metabolism |
comparison of different CDPS-containing biosynthetic pathways, the enzyme encoded by gene ndas_1148 is involved in the XR334 (i.e. (3Z,6Z)-3-benzylidene-6-[(4-methoxyphenyl)methylidene]piperazine-2,5-dione) biosynthetic pathway, overview |
-, 759890 |
| 2.3.2.20 | metabolism |
various cyclodipeptide-tailoring enzymes are found in 2,5-diketopiperazine (2,5-DKP) biosynthetic pathways |
758643 |
