EC Number   |
General Information |
Reference |
|---|
    2.3.1.54 | malfunction |
an enzyme-deletion mutant reveals a 60% decrease in invasion efficiency when compared to the wild type |
-, 757504 |
| 2.3.1.54 | malfunction |
mutation of either pflB, which codes for PFL, or pflA, which codes for pyruvate formate lyase activating enzyme, results in abrogation of mixed acid fermentation on galactose, and leads to a decrease in pneumococcal virulence |
746477 |
| 2.3.1.54 | metabolism |
anaerobic fermentation pathway yielding 3 ATP per glucose, pyruvate channeling to fermentation product, lactate dehydrogenase and pyruvate dehydrogenase are alternative pyruvate channeling enzymes during fermentation |
701826 |
| 2.3.1.54 | metabolism |
anaerobic glucose metabolism, direct link between fermentative metabolism and virulence in infected mice |
704002 |
| 2.3.1.54 | metabolism |
multiple regulators control the transcription of pflA and pflB, some of these regulators are induced by galactose, their control over pflA and pflB is influenced by sodium formate, they exert regulatory influence on each other, and are required for pneumococcal colonization and virulence. Transcriptional profile of mutant DELTApflB compared to the wild-type D39 strain, expression of seven genes annotated as transcriptional regulators is either significantly up or downregulated in the mutant, overview. CcpA, GlnR, and GntR interact with the putative promoters of pflA and pflB, impact of formate on binding affinity of CcpA and GlnR |
746477 |
| 2.3.1.54 | metabolism |
NADH generated from anaerobic glycerol metabolism in the absence of fumarate is oxidized through the pyruvate formate-lyase-ethanol fermentation pathway. Thus, the enzyme is essential to avoid the accumulation of excess NADH during fumarate-independent anaerobic glycerol metabolism |
-, 736361 |
| 2.3.1.54 | metabolism |
the enzyme can serve as a sole route for microbial growth on acetate and formate |
756036 |
| 2.3.1.54 | metabolism |
the enzyme catalyzes the conversion of pyruvate and CoA to formate and acetyl-CoA during anaerobic glucose metabolism |
757586 |
| 2.3.1.54 | metabolism |
the enzyme takes part in the metabolic pathway of pyruvate to ethanol in Thermoanaerobacterium saccharolyticum |
-, 735819 |
| 2.3.1.54 | physiological function |
anaerobic alkane degradation in Archaeoglobus fulgidus may involve the gene pflD in alkane activation through addition to fumarate |
736285 |
