EC Number   |
General Information |
Reference |
|---|
  2.3.1.289 | physiological function |
comparison of Stretomyces thiolueus aureothin and Streptomyces orinoci neoaureothin gene clusters and enzymes. In both cases individual polyketide synthase modules are used in an iterative fashion |
-, 753270 |
| 2.3.1.289 | physiological function |
heterologous expression of an engineered AurAB fusion protein. Inactivation the ketosynthase or acyl carrier domains of module 4 clearly result in a shutdown of polyketide biosynthesis. Module 4 is required for the biosynthesis of polyketide production, and, despite the apparently inactive AT4 domain, an iterative use of the entirety of module 3 seems not to take place |
-, 753269 |
| 2.3.1.289 | physiological function |
model of the itinerative action of polyketide synthase. The ACP-bound polyketide intermediate is transferred back to the ketosynthase domain on the opposite polyketide synthase strand. the AurA N-terminus is not involved in the iteration process |
-, 755024 |
| 2.3.1.289 | physiological function |
the aureothin biosynthetic gene cluster is composed of 4 modules and is encoded by three genes. The enzyme extends 4-nitrobenzoyl-CoA by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules |
-, 753232 |
