EC Number   |
General Information |
Reference |
|---|
   2.3.1.261 | malfunction |
the Dpks15 mutant has a slight reduction in radial growth and produces fewer spores compared to wild-type. Insect bioassays indicate the DELTApks15 mutant to be significantly reduced in virulence against beet armyworms compared to wild-type, which can be partially accounted for by its markedly decreased ability to survive phagocytosis. Total haemocyte count decreases sharply by 50fold from days 1-3 post-inoculation in insects infected with wild-type, compared to a 5fold decrease in the DELTApks15 mutant. The mutant also produces 3fold fewer hemolymph hyphal bodies than the wild-type. In co-culture studies with amoebae that have phagocytic ability similar to that of insect haemocytes, the mortality rate of amoebae engulfing DELTApks15 decreases by 72% during 48 h, and DELTApks15 CFU decrease by 83% compared to co-culture with the wild-type. Thus, the DELTApks15 mutant has a reduced ability to cope with phagocytosis and highly reduced virulence in an insect host |
-, 756844 |
| 2.3.1.261 | physiological function |
4-hydroxybenzoic acid-AMP ligase FadD22 catalyzes the activation of 4-hydroxybenzoic acid and its subsequent transfer onto PKS15/1, to yield 4-hydroxyphenylalkanoate. This latter lipid is then activated by 4-hydroxyphenylalkanoate adenylyltransferase FadD29 and transferred onto PpsA. Overview on biosynthesis of phthiocerol and phthiodiolone dimycocerosates |
-, 740608 |
| 2.3.1.261 | physiological function |
a gene disruption mutant is not able to produce dimycocerosyl phthiocerol, although it can produce mycocerosic acids. The mutant is attenuated in a murine model, supporting the hypothesis that dimycocerosyl phthiocerol is a virulence factor |
-, 740602 |
| 2.3.1.261 | physiological function |
a single open reading frame for pks15/1 is found in Mycobacterium bovis BCG. Disruption of the pks15/1 gene leads to the abolition of the synthesis of type-specific phenolphthiocerol glycolipid |
740673 |
| 2.3.1.261 | physiological function |
comparison of amino acid sequence homology relationships among the mas-like (msl) genes and their domain organization in Mycobacterium tuberculosis |
736399 |
| 2.3.1.261 | physiological function |
polyketide synthase gene pks1 is involved in the elongation of 4hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks1 |
740673 |
| 2.3.1.261 | physiological function |
polyketide synthase gene pks15 is involved in the elongation of 4-hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks15 |
740673 |
| 2.3.1.261 | physiological function |
the pks15/1 gene is a virulence marker in Mycobacterium tuberculosis |
-, 757424 |
