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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222evolution PduL homologues are distributed among at least 49 bacterial species but are absent from the Archaea and Eukarya. Sequence analyses show that PduL is unrelated in amino acid sequence to known phosphotransacylase, PTAC, enzymes 719708
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222evolution the phosphotransacylase (PTAC) predominantly associated with metabolosomes (PduL) has no sequence homology to the PTAC ubiquitous among fermentative bacteria (Pta). PduL and Pta exemplify functional, but not structural, convergent evolution -, 758101
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222malfunction both pduL genes (pduL1 and pduL2) are associated with acetate formation via acetyl-coenzyme A (acetyl-CoA). Their disruption enables a shift in the homoacetic pathway to the genetically synthesized homolactic pathway via pyruvate 755849
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222malfunction pduL mutants are unable to ferment 1,2-propanediol and are also impaired for aerobic growth on this compound, overview. Ectopic expression of pduL corrects the growth defects of a pta mutant, the pta gene encodes another PTAC enzyme 719708
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222metabolism both pduL genes (pduL1 and pduL2) are associated with acetate formation via acetyl-coenzyme A (acetyl-CoA). Their disruption enables a shift in the homoacetic pathway to the genetically synthesized homolactic pathway via pyruvate 755849
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222metabolism PduL is required in the 1,2-propandiol degradation pathway, overview 719708
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222metabolism the fact that PduL is confined almost exclusively to metabolosomes can be used to develop an inhibitor that blocks only PduL and not Pta as a way to selectively disrupt bacterial microcompartments(BMC)-based metabolism, while not affecting most commensal organisms that require phosphotransacylase (PTAC) activity -, 758101
Show all pathways known for 2.3.1.222Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.222physiological function PduL is a phosphotransacylase, PTAC, required for 1,2-propanediol degradation 719708
Results 1 - 8 of 8