EC Number   |
General Information |
Reference |
|---|
    2.3.1.150 | malfunction |
RNA interference of salAT leads to accumulation of the intermediate compounds, salutaridine and salutaridinol. SalAT transcript is shown by quantitative PCR to be diminished, while salutaridine reductase transcript levels remains unaffected |
700683 |
| 2.3.1.150 | malfunction |
silencing of the gene encoding SalAT results in the accumulation of salutaridine, which is not the corresponding enzymatic substrate. Reduction of SalAt transcript and protein levels results in an increase in salutaridine, i.e. an approximately 20-fold increase compared with controls, and a concomitant decrease in thebaine levels. Codeine and morphine accumulation are also significantly reduced |
720707 |
| 2.3.1.150 | metabolism |
SalAT is involved in the benzylisoquinoline alkaloid biosynthesis in opium poppy from (R)-reticuline to morphine, pathway overview |
720707 |
| 2.3.1.150 | physiological function |
yeast two-hybrid and co-immunoprecipitation analyses indicate an interaction between salutaridine reductase and SalAT, which suggest the occurrence of an enzyme complex |
700683 |
