EC Number   |
General Information |
Reference |
|---|
   2.3.1.108 | evolution |
broad phylogenetic distribution of alphaTAT1 |
720907 |
| 2.3.1.108 | evolution |
distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated |
720906 |
| 2.3.1.108 | evolution |
MEC-17 is related to the Gcn5 histone acetyltransferases |
720540 |
| 2.3.1.108 | malfunction |
a delay in cilium formation for cultured human cells depleted of alphaTAT/MEC-17 |
720906 |
| 2.3.1.108 | malfunction |
disrupting MEC17 in Tetrahymena abolishes tubulin acetylation, but no overt defect in cilium formation or motility occurs |
720906 |
| 2.3.1.108 | malfunction |
disruption of the Tetrahymena MEC-17 gene, resulting in a marked loss of acetyl-K40 in Tetrahymena cells, phenocopies the K40R alpha-tubulin mutation and makes microtubules more labile. Overexpression of GFP-Mec17p in Tetrahymena greatly increases acetylation of microtubules |
720540 |
| 2.3.1.108 | malfunction |
in animals lacking MEC-17, alphaTAT-2, and the sole Caenorhabditis elegans K40 alpha-tubulin MEC-12, touch sensation can be restored by expression of an acetyl-mimic MEC-12 K40Q. Transient overexpression of alphaTAT1 in PtK2 cells is sufficient to acetylate nearly all microtubules, whereas catalytically inactive alphaTAT1 D157N or the HAT Elp3 fail to detectably elevate alpha-tubulin K40 acetylation |
720907 |
| 2.3.1.108 | malfunction |
loss of Caenorhabditis elegans alphaTAT activity in the mec-17, atat-2 double mutant affects touch receptor neuron mechanosensation to a greater extent than having a nonacetylatable MEC-12 (K40R) form of tubulin in the organism |
720906 |
| 2.3.1.108 | malfunction |
MEC-12 is the only alpha-tubulin with K40, and mec-12(e1607) probable null allele worms have greatly reduced touch responses. Intergration of single transgenes encoding MEC-12 with either wild-type K40 or K40R or K40Q substitutions into the mec-12(e1607)mutant using Mos1 transposon excision repair restores the levels of touch response to 80% of wild type level,whereas animals with either MEC-12-K40R or MEC-12-K40Q show reduced touch response, overview |
720540 |
| 2.3.1.108 | malfunction |
overexpression of ATAT1 phenocopies the effect of HDAC6 inhibition by trichostatin. Random invasive migration of cells in 3D collagen I is inhibited by 40-50% upon MT1-MMP or ATAT1 knockdown |
719403 |
