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Results 1 - 10 of 12 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction despite deletion of gene for methionyl-tRNA still initiation of mitochondrial protein syntesis by nonformylatet Met-tRNA 704594
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction enzyme mutations are associated with Leigh syndrome, early onset mitochondrial leukoencephalopathy, microcephaly, ataxia, and cardiomyopathy 757809
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity. Loss-of-function mutations in the enzyme impart pleiotropic effects that include a reduced growth rate, a nonhemolytic phenotype, and a drastic reduction in production of multiple extracellular proteins, including key virulence factors, such as alpha-hemolysin and Panton-Valentine leukocidin, that have been associated with Staphylococcus aureus pathogenicity. Consequently, Staphylococcus aureus formyl-methionyl transferase mutants are greatly attenuated in neutropenic and nonneutropenic murine pyelonephritis infection models and show very high survival rates compared with wild-type Staphylococcus aureus. FMT-null mutants have a more severe fitness cost than previously anticipated, leading to a substantial loss of pathogenicity and a restricted ability to produce an invasive infection. Lack of transformylase affects the production of additional virulence factors, with reductions in total extracellular proteins of at least 50% observed in supernatants of cultures from the different Staphylococcus aureus WCUH29 FMT mutants -, 735441
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction heterozygous mutations in MTFMT occur in two unrelated children presenting with Leigh syndrome and combined OXPHOS deficiency. The patient fibroblasts have dramatically reduced fMet-tRNAMet levels and an abnormal formylation profile of mitochondrially translated COX1, and patient fibroblasts exhibit severe defects in mitochondrial translation that can be rescued by exogenous expression of MTFMT. Mitochondrial tRNAMet pools are abnormal in patient fibroblasts, phenotypes, overview 719239
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction mutations of conserved enzyme residues affect enzyme activity and lead to poor formylation of mitochondrial methionyl-tRNA and thereby reduced mitochondrial translation efficiency, causing Leigh syndrome 736461
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9malfunction slow growth of cells when methionyl-tRNA formyltransferase inactive, when enzyme inactive higher transcript titer of MexXY efflux pump 701743
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9metabolism formylmethionine-independent initiation of translation in apicomplexans, the requirement for an initiation by a specialized tRNA charged with formylmethionine is bypassed in the mitochondrion of these parasites, the formylated methionine used during initiation is deformylated on the nascent peptide by a peptide deformylase -, 720491
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9more in Toxoplasma gondii the absence of mitochondrial tRNA genes is compensated for by the import of cytosolic eukaryotic tRNAs. Although all compartments require a complete set of charged tRNAs, the apicomplexan nuclear genomes do not hold sufficient aminoacyl-tRNA synthetase genes to be targeted individually to each compartment. The absence of tRNAMet formyltransferase and peptide deformylase implies that the requirement for a specialized formylmethionyl-tRNAMet for translation initiation is bypassed in the mitochondrion -, 720491
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9physiological function influence on protein synthesis in mitochondria and chloroplasts by producing a formylated initiator methionyl-tRNA 704594
Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.9physiological function MTFMT is critical for efficient human mitochondrial translation 719239
Results 1 - 10 of 12 > >>