EC Number   |
General Information |
Reference |
|---|
   2.1.1.257 | evolution |
m1PSI formation in archaeal tRNAs, overview. The enzyme belongs to Cluster of Orthologous Group, COG, 1901 |
-, 721041 |
| 2.1.1.257 | evolution |
Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases |
-, 720582 |
| 2.1.1.257 | evolution |
phylogeny of the methyltransferase family, overview |
721040 |
| 2.1.1.257 | evolution |
the enzyme is a member of the SPOUT-class family of RNA methyltransferases, phylogeny of the methyltransferase family, overview |
721040 |
| 2.1.1.257 | evolution |
the enzyme is a SPOUT-class RNA methyltransferase and belongs to the DUF358 family. The DUF358/Mj1640 protein shows close structural relationship to Nep1, a pseudouridine-N1-specific rRNA methyltransferase |
720274 |
| 2.1.1.257 | malfunction |
a Hvo_1989 knockout strain lacks N1-methyl pseudouridine modifications at position 54 of its tRNAs, the in-frame deletion of the pseudouridine N1-methyltransferase gene in Haloferax volcanii does not result in a discernable phenotype |
721040 |
| 2.1.1.257 | malfunction |
a mutation in the human Nep1 homolog causes Bowen-Conradi syndrome, a severe developmental disorder |
720582 |
| 2.1.1.257 | malfunction |
deletion of trmY leads to the absence of m1PSI54 in Haloferax volcanii tRNA |
721041 |
| 2.1.1.257 | metabolism |
Pus10-mediated PSI54 (and PSI55) formation does not require the presence of TrmY activity, overview |
721041 |
| 2.1.1.257 | more |
Methanocaldococcus jannaschii TrmY requires C55 (or possibly U55) in the tRNA to produce m1PSI54 |
721041 |
