EC Number   |
General Information |
Reference |
|---|
   2.1.1.137 | malfunction |
a gene disruption mutant loses arsenite methylation ability and becomes more sensitive to arsenite |
-, 733175 |
| 2.1.1.137 | metabolism |
key enzyme in the pathway for methylation of arsenicals |
721075 |
| 2.1.1.137 | metabolism |
splicing of AS3MT pre-mRNA is disconcerted by oxidative stress and abnormal alternative splicing of AS3MT mRNA may affect arsenic methylation ability. Exposure of HepG2 cells to H2O2 results in increased levels of a spliced form skipping exon-3 to exon-10 in an H2O2-concentration-dependent manner |
755943 |
| 2.1.1.137 | physiological function |
Bacillus subtilis 168 expressing ArsM converts most of the inorganic As in the medium into dimethylarsenate and trimethylarsine oxide within 48 h and volatizes substantial amounts of dimethylarsine and trimethylarsine. The rate of As methylation and volatilization increases with temperature from 37 to 50°C. When inoculated into an As-contaminated organic manure composted at 50°C, the modified strain significantly enhances As volatilization |
755840 |
| 2.1.1.137 | physiological function |
expression of ArsM confers resistance to an As(III)-hypersensitive strain of Escherichia coli |
757684 |
| 2.1.1.137 | physiological function |
N6AMT1 converts monomethylarsonous acid(III) into the less toxic dimethylarsonic acid (V). The effects of N6AMT1 in arsenic metabolism are relatively minor and limited when compared with the action of As3MT |
758507 |
| 2.1.1.137 | physiological function |
the enzyme plays a role in arsenite methylation and detoxification of As3+ |
-, 733175 |
| 2.1.1.137 | physiological function |
the enzyme plays an important role in the detoxification of arsenicals |
718748 |
