EC Number   |
General Information |
Reference |
|---|
  2.1.1.1 | malfunction |
alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant |
733737 |
| 2.1.1.1 | malfunction |
depletion of NNMT affects chemotaxis and chemokinesis |
706009 |
| 2.1.1.1 | malfunction |
enzyme NNMT plays an important role in PANC-1 cell proliferation, metastatic potential and survival under metabolic stress. Enzyme silencing markedly reduces cell proliferation, whereas enzyme overexpression promotes cell growth moderately. Knockdown of NNMT also significantly suppresses the migration and invasion capacities of pancreatic cancer PANC-1 cells. Enzyme NNMT upregulation enhances cell migration and invasion capacities. In addition, NNMT knockdown cells are much less resistant to glucose deprivation and rapamycin as well as glycolytic inhibitor 2-deoxyglucose whereas NNMT-overexpressing cells show opposite effects although the effects are not so striking |
733636 |
| 2.1.1.1 | malfunction |
nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma |
735327 |
| 2.1.1.1 | malfunction |
shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells |
733449, 733618 |
| 2.1.1.1 | malfunction |
suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have significantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes |
-, 734757 |
| 2.1.1.1 | malfunction |
the enzyme effects on neurons are reduced in cells lacking epinephrin EFNB2 or Akt |
733625 |
| 2.1.1.1 | metabolism |
enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability |
-, 734757 |
| 2.1.1.1 | metabolism |
NNMTexpression is significantly positively associated with pAkt/protein kinase B expression |
735327 |
| 2.1.1.1 | metabolism |
the effects of enzyme NNMT expression in SH-SY5Y cells, e.g. protection against the toxicity of the Complex I (CxI) inhibitors 1-methyl-4-phenylpyridinium ion and rotenone, are mediated via increased CxI activity and ATP production and the sequential activation of the epinephrin EFNB2 and Akt signalling pathways |
733625 |
