EC Number |
General Information |
Reference |
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1.5.8.4 | malfunction |
rare natural mutation H109R, causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations |
742499 |
1.5.8.4 | metabolism |
the enzyme takes part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain |
742499 |
1.5.8.4 | metabolism |
the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed |
743378 |
1.5.8.4 | physiological function |
dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway |
743378 |
1.5.8.4 | physiological function |
DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed |
743378 |
1.5.8.4 | physiological function |
during the process of intestine regeneration, there are significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration and normal intestines. Genes encoding betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase are differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration |
764528 |
1.5.8.4 | physiological function |
the enzyme suppresses metastasis in hepatocellular carcinoma |
743378 |