EC Number   |
General Information |
Reference |
|---|
    1.5.3.16 | evolution |
AtPAO2-AtPAO4 form a subfamily of polyamine oxidases different from AtPAO1, overview |
-, 725625 |
| 1.5.3.16 | evolution |
isozyme SMOalpha displays a significant sequence similarity with the structurally characterized polyamine oxidase from maize |
723918 |
| 1.5.3.16 | evolution |
phylogenetic analysis and structure-function relationships of spermine oxidases among vertebrates, overview. Polar residues (His82, Gln200, Glu224, Tyr482, Ser527, Thr528) and hydrophobic residues (Trp80 and Trp427), hypothesized to bind spermine in the correct position, are strictly conserved in all SMOs |
725753 |
| 1.5.3.16 | evolution |
phylogenetic analysis and structure-function relationships of spermine oxidases among vertebrates, ubiquitous occurrence of these SMO isoforms in placental mammals, overview. Polar residues (His82, Gln200, Glu224, Tyr482, Ser527, Thr528) and hydrophobic residues (Trp80 and Trp427), hypothesized to bind spermine in the correct position, are strictly conserved in all SMOs |
725753 |
| 1.5.3.16 | malfunction |
AtPAO4 deficiency induces alterations in the expression of genes related to the drought stress response and flavonoid biosynthesis |
694651 |
| 1.5.3.16 | malfunction |
decreased expression of SMO is observed in brains of suicide completers. SMO dysregulation can alter polyamine homeostasis affecting polyamine catabolism, which has been observed to be often associated with several disease states. The late induction of SMO correlates very well with Spm increase in the ipsilateral injured regions compared to equivalent controlateral regions, suggesting that SMO activity might be elevated at later times post-injury. Spermine oxidation may also be considered a source of secondary tissue damage, increased inflammation and apoptotic cell death in the injured brain |
723918 |
| 1.5.3.16 | malfunction |
loss-of-function mutants contain 2-fold higher thermospermine levels and exhibit delayed transition from vegetative to reproductive growth compared with that of wild-type plants |
743491 |
| 1.5.3.16 | malfunction |
reduced spermine oxidase expression may contribute to muscle atrophy during a variety of stress conditions, including immobilization, denervation, fasting, and aging |
741571 |
| 1.5.3.16 | malfunction |
SMO dysregulation can alter polyamine homeostasis affecting polyamine catabolism, which has been observed to be often associated with several disease states |
723918 |
| 1.5.3.16 | metabolism |
SMO is a key enzyme of polyamine catabolism, metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases, overview |
723916 |
