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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.23malfunction methylglyoxal accumulation leads to G2-phase arrest by affecting cell growth, ROS production, viability, differentiation, and virulence. Phenotypes of enzyme-deficient cells, overview 742509
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.23physiological function the enzyme catalyzes both methylglyoxal oxidation to pyruvate as well as its reduction to acetol. ADH1 activity likely shifts between methylglyoxal oxidation and reduction with a marked change in the intracellular redox state during the growth, such as GSH starvation. The enzyme is required for regulation of methylglyoxal content in the cell. Mgd activity is highly induced in GSH-deficient cells 742509
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