EC Number |
General Information |
Reference |
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1.2.1.13 | malfunction |
a deletion mutant strain does not exhibit any growth under gluconeogenic conditions |
726000 |
1.2.1.13 | malfunction |
several GAPDH isozymes are targets of persulfidation, including NAD- and NADP-dependent GAPDH (GAPC1, GAPC2, GAPA1, and ALDH11A3). The in vitro assay of Arabidopsis leaf extracts in the presence of NaHS show an activity increase of 60% which is reversed by DTT |
761625 |
1.2.1.13 | metabolism |
Diatom plastids lack of the oxidative pentose phosphate pathway, and so cannot produce NADPH in the dark. The observed downregulation of GAPDH in the dark may allow NADPH to be rerouted towards other reductive processes contributing to their ecological success |
743366 |
1.2.1.13 | metabolism |
posttranslational modifications promoted by NO (tyrosine nitration and S-nitrosation), H2S (persulfidation), and glutathione (glutathionylation), affect the cellular redox status through regulation of the NADP-dependent dehydrogenases. Major regulatory mechanisms of the NADPH-generating enzymes by NO and H2S in higher plants, with particular focus on the PTMs mediated by reactive nitrogen species (RNS) and and reactive sulfide species (RSS), overview |
761625 |
1.2.1.13 | metabolism |
posttranslational modifications promoted by NO (tyrosine nitration and S-nitrosation), H2S (persulfidation), and glutathione (glutathionylation), affect the cellular redox status through regulation of the NADP-dependent dehydrogenases. Major regulatory mechanisms of the NADPH-generating enzymes by NO and H2S in higher plants, with particular focus on the PTMs mediated by reactive nitrogen species (RNS) and reactive sulfide species (RSS), overview |
761625 |
1.2.1.13 | metabolism |
the enzyme plays a major role only in gluconeogenesis |
726000 |
1.2.1.13 | metabolism |
the limited availability of nitrogen (N) is a fundamental challenge for many crop plants. The relative crop photosynthetic rate (P) is exponentially constrained by certain plant-specific enzyme activities, such as ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), NADP-glyceraldehyde-3-phosphate dehydrogenase (NADP-G3PDH), 3-phosphoglyceric acid (PGA) kinase, and chloroplast fructose-1,6-bisphosphatase (cpFBPase), in Oryza sativa |
763095 |
1.2.1.13 | metabolism |
the limited availability of nitrogen (N) is a fundamental challenge for many crop plants. The relative crop photosynthetic rate (P) is exponentially constrained by certain plant-specific enzyme activities, such as ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), NADP-glyceraldehyde-3-phosphate dehydrogenase (NADP-G3PDH), 3-phosphoglyceric acid (PGA) kinase, and chloroplast fructose-1,6-bisphosphatase (cpFBPase), in Triticum aestivum |
763095 |
1.2.1.13 | physiological function |
GAPDH has a strategic position within cell metabolism because GAP is an intermediate in many metabolic pathways, and therefore GAPDH needs to be highly regulated. In cyanobacteria, green and red algae and higher plants, GAPDH and phosphoribulokinase (PRK, EC 2.7.1.19) are downregulated by forming a ternary complex with CP12. Regulation of the key Calvin cycle enzymes of diatom algae differs from that of the Plantae. Enzyme GAPDH interacts with ferredoxin-nicotinamide adenine dinucleotide phosphate (NADP) reductase (FNR) from the primary phase of photosynthesis, and the small chloroplast protein, CP12 |
743366 |
1.2.1.13 | physiological function |
gluconeogenic pathway |
-, 724980 |