EC Number   |
General Information |
Reference |
|---|
   1.16.1.10 | malfunction |
ferric chelate reductase 1 like protein (FRRS1L) mutations in human lead to epilepsy, choreoathetosis, and cognitive deficits. Overexpression of enzyme FRRS1L in hippocampal neurons does not change glutamatergic synaptic transmission, but single-cell knockout of FRRS1L strongly reduces the surface and total expression levels of GluA1 in cultured hippocampal neurons, and significantly decreases AMPAR-mediated synaptic transmission in mouse hippocampal pyramidal neurons |
-, 744983 |
| 1.16.1.10 | malfunction |
lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity, leading to chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions, phenotype, overview |
-, 746145 |
| 1.16.1.10 | metabolism |
the protein kinase CIPK23 is involved in iron acquisition. Lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by downregulating ferric chelate reductase activity. Iron deficiency evokes an increase in cytosolic Ca2+ concentration, and the elevated Ca2+ binds to CBL1/CBL9, leading to activation of CIPK23, CBL-CIPK23complexes might be as nutritional sensors to sense and regulate the mineral homeostasis in Arabisopsis thaliana. Regulation of FCR activity by CIPK23 may not be achieved by modulation of genes FRO2, FRO3 and FRO5 at transcriptional level |
-, 746145 |
| 1.16.1.10 | physiological function |
dissimilatory reduction of iron |
-, 722516 |
| 1.16.1.10 | physiological function |
FCR activity in plants not only depends on FRO expression, abundance of FRO proteins, and but also depends on the levels of heme, ATP and NADPH/NADH |
-, 746145 |
| 1.16.1.10 | physiological function |
iron has an essential role in the biosynthesis of chlorophylls and redox cofactors, and thus chloroplast iron uptake is a process of special importance. The chloroplast ferric chelate oxidoreductase (cFRO) has a crucial role in this process |
745899 |
| 1.16.1.10 | physiological function |
recombinant FRRS1L interacts with both GluA1 and GluA2 subunits of AMPA receptors, AMPARs, but does not form dimers/oligomers, in HEK293 cells. Important role of FRRS1L in the regulation of excitatory synaptic strength. FRRS1L is a component of native AMPAR complexes in the brain |
-, 744983 |
