EC Number   |
General Information |
Reference |
|---|
   1.14.99.36 | evolution |
BCMO1 is a member of an evolutionary well-conserved family of carotenoid cleavage oxygenases |
-, 726818 |
| 1.14.99.36 | malfunction |
a nonsense mutation c.196C-T in the beta-carotene oxygenase 2 BCO2 gene is strongly associated with the yellow fat phenotype in sheep that is caused by accumulation of carotenoids in adipose tissue, a recessive trait. But animals homozygous for the mutation do not suffer from any negative health or development traits, pointing towards a minor role of BCO2 in vitamin A formation |
714616 |
| 1.14.99.36 | malfunction |
BCMO1 knock-out mice become vitamin A deficient despite expressing BCDO2. Hepatic BCDO2 expression is significantly elevated in BCMO1 KO mice compared with wild-type mice, leading to a significant increase in beta-apo-12'-carotenal or beta-apo-10'-carotenal concentration. BCMO1 KO mice reveal a large accumulation of beta-carotene in tissues (liver, lung, adipose tissue) of animals on a beta-carotene-enriched diet. Increased susceptibility of BCMO1 KO mice to diet induced obesity, coupled with increased expression of PPAR-gamma-induced genes. Knockout of BCMO1 alters serum lipid levels and leads to the development of liver steatosis in mice |
728342 |
| 1.14.99.36 | malfunction |
Bcmo1-/- mice show increased expression of Bcdo2 in adipocytes and beta-10'-apocarotenol accumulates as the major beta-carotene derivative. Bcmo1-/- mice have a lower average body weight than wild-type mice |
728552 |
| 1.14.99.36 | malfunction |
genetic disruption of BCO1 results in beta-carotene accumulation and vitamin A deficiency accompanied by a BCO2-dependent production of minor amounts of beta-apo-10'-carotenol, which can be esterified and transported by the same proteins as vitamin A but with a lower affinity and slower reaction kinetics. all-trans-Retinol treatment of vitamin A-deprived Bco1-/- mice decreases hepatic retinol-binding protein levels |
727965 |
| 1.14.99.36 | malfunction |
lack of CMOI in the developing tissues further exacerbates the severity of vitamin A deficiency and thus the embryonic malformations of retinol-binding protein-deficient mice, phenotypes, overview |
727462 |
| 1.14.99.36 | malfunction |
reduced BCMO1 expression in normal preneoplastic intestine of folate-deficient tumor-prone mice. A mouse model develops intestinal tumors after low dietary folate |
726652 |
| 1.14.99.36 | malfunction |
transfection of cells with BCMO1 siRNA inhibits BCMO1 expression, enhances cancer migration and invasion, and increases expression of MMP7 and MMP28 |
726652 |
| 1.14.99.36 | metabolism |
Bcmo1 and retinal dehydrogenase 1 are key enzymes in the retinoid metabolism of inguinal white adipose tissue |
715535 |
| 1.14.99.36 | metabolism |
beta-carotene 15,15'-monooxygenase is a key enzyme in vitamin A metabolism |
726819 |
