1.14.19.19 | physiological function |
the enzyme catalyzes the regiospecific biosynthesis of fusaruside, a 10,11-unsaturated immunosuppressive fungal sphingolipid through desaturation of cerebroside B, an abundant fungal sphingolipid. The conserved histidines of DELTA 10(E)-SD are essential for the 10,11-desaturation catalysis, which is also preconditioned by the C9-methylation of the substrate. Enzyme DELTA 10(E)-SD improves survival of fungal strains in chill and salinity |
-, 746436 |