EC Number   |
General Information |
Reference |
|---|
    1.14.15.6 | metabolism |
conversion of cholesterol to pregnenolone by P450scc represents the initiation of steroidogenesis |
703100 |
| 1.14.15.6 | metabolism |
Cyp11a is responsible for the first step in steroidogenesis, catalyzing the conversion of cholesterol to prognenolone |
711826 |
| 1.14.15.6 | metabolism |
CYP11A1 is a Runx2-responsive gene and may represent an integral component of a biological program that is controlled by Runx2 to regulate enzymes mediating sterol/steroid metabolism |
705739 |
| 1.14.15.6 | metabolism |
vitamin D2 metabolism occurs with lower efficiency than that observed for both cholesterol and D3 metabolism by P450scc |
703418 |
| 1.14.15.6 | more |
the active site cavity in CYP11A1 represents a long curved tube that extends from the protein surface to the heme group, the site of catalysis. Shuttling of the sterol intermediates between the active site entrance and the heme group during the three-step reaction. Structural basis of the strict substrate specificity and high catalytic efficiency of the enzyme, overview |
725459 |
| 1.14.15.6 | physiological function |
CYP11A1 suppresses osteoblast proliferation, specific CYP11A1 knockdown with short hairpin RNA increases cell proliferation |
705739 |
| 1.14.15.6 | physiological function |
cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3, as well as 1-hydroxyvitamin D3 to 1alpha,20-dihydroxyvitamin D3. It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone, which can be transformed to 20-hydroxy-7-dehydropregnenolone. The secosteroids inhibit proliferation and induce erythroid differentiation of diverse leukemic cells, and are only slightly less potent than 1,25-dihydroxy-vitamin D3, but show no or lower calcemic activity compared to 1,25-dihydroxy-vitamin D3, molecular modeling, overview |
713379 |
| 1.14.15.6 | physiological function |
endocrine disrupting chemical modulation of acute steroid hormone regulation by targeting StAR and P450scc may have severe consequences for the entire reproduction process, including oocyte growth, development and overt fecundity |
703100 |
| 1.14.15.6 | physiological function |
Escherichia coli membrane interacting peptides in CYP11A1 are from the putative F-G loop (residues 218-225) and the C-terminal portion of the G helix (residues 238-250) |
705461 |
| 1.14.15.6 | physiological function |
expression of StAR and P450scc transcripts is related to steroid synthesis |
703100 |
