EC Number |
General Information |
Reference |
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1.14.15.3 | malfunction |
loss-of-function cyp86B1/ralph mutants display a novel suberin monomer composition. Complete knockout of CYP86B1 in ralph1 and ralph2 leads to an almost complete lack of C22 and C24 omega-hydroxyacids and alpha,omega-dicarboxylic fatty acids in the seed coat polyester and is accompanied by a strong increase in C22 and C24 unsubstituted, saturated fatty acids |
706305 |
1.14.15.3 | malfunction |
mutations in CYP703A2 or CYP704B1 genes result in pollen with remarkably similar zebra phenotypes (impaired pollen walls that lack a normal exine layer and exhibit a characteristic striped surface). Double and triple mutant combinations do not result in the appearance of novel phenotypes or enhancement of single mutant phenotypes |
706321 |
1.14.15.3 | malfunction |
several diseases are genetically linked to the expression of CYP4 gene polymorphic variants, which may link human susceptibility to diseases of lipid metabolism and the activation and resolution phases of inflammation |
702154 |
1.14.15.3 | malfunction |
suppression or knockout of sxe1 significantly reduces mating success in males throughout the diurnal cycle |
703870 |
1.14.15.3 | metabolism |
CYP4A functions in liver fatty acid metabolism |
702154 |
1.14.15.3 | metabolism |
CYP4A functions in liver fatty acid metabolism. Increased expression of the CYP4A omega hydroxylase during steatohepatitis and their induction in animals fed a high fat diet suggest they may play a pivotal role in preventing lipotoxicity, and may be responsible for induction of oxidative stress and progression to steatohepatitis. Omega-hydroxylation of the CYP2C arachidonic acid metabolite epoxyeicosatrienonic acid to omega-hydroxylated eicosatrienoic acid can induce peroxisome proliferation in rodents |
702154 |
1.14.15.3 | metabolism |
CYP4A11 is the least efficient CYP450 omega-hydroxylase in PUFA metabolism. PUFA hydroxylation by CYP4A11 is low and only slightly regiospecific |
704996 |
1.14.15.3 | metabolism |
multiple alkane hydroxylase systems ensure the utilization of substrates of a broad chain length range |
-, 724856 |
1.14.15.3 | metabolism |
the metabolomic profile of wild-type and sxe1 mutant males reveals that sxe1 likely functions as a fatty acid omega-hydroxylase, suggesting that male courtship and mating success is mediated by small compounds generated by this enzyme |
703870 |
1.14.15.3 | more |
AlkB contains a nonheme diiron center as a catalytic site |
-, 713529 |