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1.14.14.94
metabolism
CYP4F catalyzes the omega-hydroxylation of the side chain of tocopherols and tocotrienols, the first step in their catabolism to polar metabolites excreted in urine. CYP4F2 is the only enzyme currently shown to metabolize vitamin E in humans
712833
1.14.14.94
physiological function
by regulating the balance of leukotriene B4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis
703013
1.14.14.94
physiological function
CYP4F3B plays a central role in the inactivation and elimination of leukotrienes from systemic circulation during the resolution of inflammation
741555
1.14.14.94
physiological function
is critical in the inactivation of leukotriene B4 in polymorphonuclear leukocytes with a -fold induction between 3 and 71
703413
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