EC Number   |
General Information |
Reference |
|---|
   1.14.14.73 | metabolism |
metabolism of albendazole to albendazole-sulfoxide by pig liver microsomes is dependent on both microsomal cytochrome P-450 and FAD-containing mono-oxygenase enzymes. the relative contributions of the two systems depend on the concentration of albendazole |
746557 |
| 1.14.14.73 | physiological function |
flavin monoxygenases and cytochrome P450 reductase contribute about 30% and 70%, respectively, to albendazole S-oxide production in vitro. CYP3A4 is the mainly contributing cytochrome component |
744610 |
| 1.14.14.73 | physiological function |
in liver perfusion fluid of albendazole-treated animals, the concentration of albendazole-sulfoxide remains unchanged, as compared to control animals, whereas albendazole-sulfone is increased in treated animals |
745602 |
| 1.14.14.73 | physiological function |
two main enzymatic systems, cytochrome P450s and flavin-containing monooxygenase, are responsible for the sulfoxidation of albendazole. P450 inhibitors inhibit the production of (-)-albendazole S-oxide more than the production of (+)-albendazole S-oxide |
744768 |
