EC Number   |
General Information |
Reference |
|---|
   1.14.14.29 | metabolism |
CYP7B1 is an enzyme expressed in many human tissues and implicated in cholesterol metabolism. In the liver, this protein is part of the alternate/acidic pathway for primary bile acid production while in brain, CYP7B1 provides the primary metabolic route for cholesterol derivatives dehydroepiandrosterone and related hydroxysteroids via 7alpha-hydroxylation |
711775 |
| 1.14.14.29 | more |
spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview |
711775 |
| 1.14.14.29 | physiological function |
activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens |
702427 |
| 1.14.14.29 | physiological function |
CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens |
702427 |
| 1.14.14.29 | physiological function |
important role for CYP7B1 in cellular growth, particularly in connection with estrogenic signalling |
705397 |
| 1.14.14.29 | physiological function |
key enzyme in bile acid synthesis by the alternative pathway |
695480 |
| 1.14.14.29 | physiological function |
pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice |
705003 |
