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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50evolution evolution of PCP catabolic genes in BtAOA, overview -, 764798
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50evolution the enzyme belongs to the Bacillus cereus group in the Phe4MO superfamily, sequence comparisons and phylogenetic analysis -, 763935
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50metabolism degradation of pentachlorophenol 744327
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50metabolism hydroxylation of pentachlorophenol in the pentachlorophenol biodegradation pathway 700529
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50metabolism the first step in the PCP degradation pathway is the rate-limiting step involving the hydroxylation of PCP to 1,4-tetrachlorobenzoquinone (Tet-CBQ). The reaction is catalysed by the enzyme PCP 4-monooxygenase (PcpB) in bacteria and cytochrome p450 monooxygenase in fungus. Phe4MO also plays a critical role in xenobiotic compound degradation and lipid metabolism -, 763935
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50metabolism two pathways are proposed for pentachlorophenol (PCP) transformation in BtAOA. In the first pathway, 2,6-bis(1,1-dimethylethyl)phenol, 1-methoxy-5-trimetylsilyoxyhexane, trimethylsilyl 2-butoxyacetate and methyl 2-hydroxyl-3-methylbutanoate fragments are found. The metabolites detected for the proposed second pathway include 1,3-dimethyl-4,6-diisopropylbenzene, 2,4-dimethylbenzenecarboxaldehyde and 2,5-dimethylbenzaldehyde. Both 2,6-di-tert-butylbenzoquinone and 1,3-dimethyl-4,6-diisopropylbenzene cannot be metabolites from the same pathway, it could be that, one of the pathways is initiated by PcpB and the other by cytochrome P450 monooxygenase. Metabolic reconstruction of BtAOA xenobiotics biodegradation pathways, pathway regulation analysis, overview -, 764798
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50more enzyme homology structure modeling using PDB IDs 4Q3W and 4JPY individually as templates, overview. The catalytic active site of the enzyme has a Fe3+ metal ion-binding centre in contact with residues His124, Glu125, His129 and Glu214 -, 763935
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.50physiological function efficient degradation of pentachlorophenol (PCP) and involvement of different genes and enzymes in the degradation pathway in Bacillus tropicus strain AOA-CPS1 -, 763935
Results 1 - 8 of 8