EC Number   |
General Information |
Reference |
|---|
  1.14.13.212 | evolution |
genes involved in the caffeine C-8 oxidation pathway are located in a 25.2-kb genomic DNA fragment of CBB1, including cdhABC (coding for caffeine dehydrogenase) and tmuM (coding for TmuM), Physical map of genes for caffeine transformation in a 25.2-kb gene cluster in Pseudomonas sp. strain CBB1, overview |
727759 |
| 1.14.13.212 | metabolism |
the enzyme takes part in the caffeine C-8 oxidation pathway as the second enzyme, a NADH-dependent trimethyluric acid monooxygenase that catalyzes the conversion of trimethylurate to 1,3,7-trimethyl-5-hydroxyisourate. This product spontaneously decomposes to racemic 3,6,8-trimethylallantoin |
727759 |
| 1.14.13.212 | metabolism |
two distinct caffeine metabolic pathways in bacteria: N-demethylation and C-8 oxidation, the NADH-dependent trimethyluric acid monooxygenase is involved in the latter catalyzing the second step of the C-8 oxidation pathway, overview |
736746 |
| 1.14.13.212 | more |
homology models of trimethyluric acid monooxygenase against uric acid oxidase HpxO (which catalyzes uric acid to 5-hydroxyisourate) reveal a much bigger and hydrophobic cavity to accommodate the larger substrates |
727759 |
