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Results 1 - 10 of 23 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function at the blastula stage, Jmjd3, Utx and H3K27 methylase Ezh2 show similar expression patterns in the animal cap and marginal zone that give rise to the ectoderm and mesoderm, respectively. The three genes maintain similar expresxadsion patterns in the neural plate, preplacodal ectoderm and axial mesoderm during the gastrula and neurula stages. Later, expression is maintained in the developing brain and cranial sensory tissues, such as the eye and ear, of tailbud embryos 753885
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function both demthylase Utx and Jmjd3 redundantly promote H3K27Me3 removal at, and expression of, a specific subset of genes involved in terminal thymocyte differentiation, especially S1pr1, encoding a sphingosine-phosphate receptor required for thymocyte egress. Thymocyte expression of S1pr1 is not rescued in Jmjd3- and Utx-deficient male mice, which carry the catalytically inactive Utx homolog Uty 754833
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function demethylase UTX mediates removal of H3K27me3 at the Myog and CKm genes. Transactivator Six4 initially recruits UTX to the regulatory region of muscle genes. The resulting loss of H3K27me3 marks is limited to the region upstream of the transcriptional start site. Blocking polymerase Pol II elongation on transcribed genes leads to increased H3K27me3 within the coding region, and formation of bivalent (H3K27me3/H3K4me3) chromatin domains 753418
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function during the monolayer differentiation of mouse embryonic stem cells into neural stem cells, Jmjd3 controls the expression of key regulators and markers of neurogenesis and is required for commitment to the neural lineage. Jmjd3 targets show distinct patterns of H3K27 methylation and expression 755189
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function histone demethylase JMJD3 regulates the expression of neutrophil membrane proteinase 3 (mPR3, EC 3.4.21.76) in lipopolysaccharide-stimulated neutrophils, mostly during the early inflammatory response in sepsis. JMJD3 regulates the expression of mPR3 by changing the level of H3K27me3 in LPS-stimulated neutrophils 753821
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function histone H3 lysine-27 demethylation crucially regulatesT helper cell Th17 differentiation. Activation of naive CD41 T cells immediately induces high expression of Jmjd3. Genetic depletion of Jmjd3 in CD41 T cells specifically impairs Th17 cell differentiation both in vitro and in vivo. Jmjd3-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis. Inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppresses Th17 cell differentiation in vitro. Jmjd3 directly binds to and reduces the level of H3K27 trimethylation (me3) at the genomic sites of Rorc 754443
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function histone H3K27 demethylase JMJD3 regulates the fragmentation of spermatogonial cysts. Down-regulation of Jmjd3 in spermatogonial stem cells promotes an increase in undifferentiated spermatogonia but does not affect their differentiation. Germ cell-specific Jmjd3 null male mice have larger testes and sire offspring for a longer period compared to controls. Jmjd3 deficiency induces frequent fragmentation of spermatogonial cysts by abscission of intercellular bridges 755198
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function inhibition of Utx1 results in misregulation of hox genes and a striking posterior developmental defect, which is partially rescued by wild-type, but not by catalytically inactive, human Utx 754877
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. Ectopic expression of JMJD3 leads to a strong decrease of H3K27me3 levels and causes delocalization of polycomb proteins in vivo. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development 754878
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.68physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development 754878
Results 1 - 10 of 23 > >>