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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32evolution the enzyme belongs to the 2-oxoglutarate/Fe(II)-dependent dioxygenase superfamily 725537
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32malfunction virus-induced gene silencing of CODM in opium poppy efficiently blocks metabolism at codeine 700357
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32metabolism codeine O-demethylase catalyzes the last step of morphine biosynthesis in opium poppy 725537
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32metabolism the enzyme is involved in the morphinan pathway via codeine of the biosynthesis of benzylisoquinoline alkaloids in Papaver somniferum, overview 724726
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32metabolism thebaine binds at the two distinct sites of thebaine 6-O-demethylase T6ODM, Ec 1.14.11.31, and codeine-3-O-demethylase CODM, which determines the precise regioselectivity at C6 and C3 positions of thebaine respectively. Thebaine binds in site II (characteristic due to the presence of Asp313) of T6ODM for C6 selectivity. It binds in site I (characteristic due to the presence of Asp143) of CODM for C3 selectivity. Thebaine forms stable ionic interaction with these aspartate residues via its positively charged tertiary amino group and is further stabilized by the hydrophobic interactions via its B ring. The binding of oxygen to the nonheme iron is followed by the Fe(IV)=O bond flip, yielding an octahedral intermediate. During the decarboxylation reaction process, the C-terminal lid in the enzyme changes from the closed conformation in the 5C coordinate Fe(IV)=O complex to an active open conformation in the 6C coordinate complex 764840
Show all pathways known for 1.14.11.32Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.32physiological function codeine O-demethylase catalyzes the last step of morphine biosynthesis in opium poppy, but it also catalyze the O,O-demethylenation of methylenedioxy bridges on protopine alkaloids. No or poor activity with papaverine, (R,S)-tetrahydropapaverine, (R,S)-canadine, (R,S)-stylopine, berberine, and oripavine 725537
Results 1 - 6 of 6