EC Number |
General Information |
Reference |
---|
1.1.99.39 | drug target |
the dependence of Pseudomonas aeruginosa on PaD2HGDH makes the enzyme a potential therapeutic target against Pseudomonas aeruginosa |
762735 |
1.1.99.39 | evolution |
a phylogenetic tree analysis of D-2-hydroxyglutarate dehydrogenase from Pseudomonas aeruginosa, vanillyl alcohol oxidase, and human D-2-hydroxyglutarate dehydrogenase establishes genetic diversity among these enzymes |
762735 |
1.1.99.39 | malfunction |
deletion mutant displays decreased growth. The defect is rescued by adding L-serine |
-, 763643 |
1.1.99.39 | metabolism |
the enzyme elevates 2-oxoglutarate levels, influencing histone and DNA methylation, and HIF1alpha hydroxylation, and induces mitochondrial isocitrate dehydrogenase activity |
741050 |
1.1.99.39 | physiological function |
the enzyme catalyzes a necessary step in the serine biosynthetic pathway |
762735 |
1.1.99.39 | physiological function |
the enzyme directly reduces recombinant human electron transferring flavoprotein (ETF), thus establishing a metabolic link between the oxidation of D-2-hydroxyglutarate and the mitochondrial electron transport chain |
762750 |
1.1.99.39 | physiological function |
the enzyme is functionally tied to L-serine synthesis. D-2-Hydroxyglutarate-mediated coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis |
-, 763643 |
1.1.99.39 | physiological function |
the enzyme plays a dual role in L-serine biosynthesis and D-malate utilization |
-, 763256 |