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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39drug target the dependence of Pseudomonas aeruginosa on PaD2HGDH makes the enzyme a potential therapeutic target against Pseudomonas aeruginosa 762735
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39evolution a phylogenetic tree analysis of D-2-hydroxyglutarate dehydrogenase from Pseudomonas aeruginosa, vanillyl alcohol oxidase, and human D-2-hydroxyglutarate dehydrogenase establishes genetic diversity among these enzymes 762735
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39malfunction deletion mutant displays decreased growth. The defect is rescued by adding L-serine -, 763643
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39metabolism the enzyme elevates 2-oxoglutarate levels, influencing histone and DNA methylation, and HIF1alpha hydroxylation, and induces mitochondrial isocitrate dehydrogenase activity 741050
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39physiological function the enzyme catalyzes a necessary step in the serine biosynthetic pathway 762735
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39physiological function the enzyme directly reduces recombinant human electron transferring flavoprotein (ETF), thus establishing a metabolic link between the oxidation of D-2-hydroxyglutarate and the mitochondrial electron transport chain 762750
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39physiological function the enzyme is functionally tied to L-serine synthesis. D-2-Hydroxyglutarate-mediated coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis -, 763643
Display the word mapDisplay the reaction diagram Show all sequences 1.1.99.39physiological function the enzyme plays a dual role in L-serine biosynthesis and D-malate utilization -, 763256
Results 1 - 8 of 8