EC Number   |
General Information |
Reference |
|---|
    1.1.5.3 | malfunction |
despite the widespread expression of the enzyme, mGPDH-knockout mice display relatively mild phenotypes beyond weaning. These include decreased body mass and decreased white fat mass |
-, 741302 |
| 1.1.5.3 | malfunction |
in the absence of Gpd2, hyperactivation and acrosome reaction are significantly altered, and a few changes in protein tyrosine phosphorylation are observed during sperm capacitation. The testicular size of Gpd2-deficient animals is about 10% smaller than in wild type animals. Gpd2-null animals show a 4% reduction in tubular diameter and about 10% reduction in numbers of both spermatocytes and spermatids per seminiferous tubule |
713077 |
| 1.1.5.3 | metabolism |
the enzyme is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism |
740095 |
| 1.1.5.3 | physiological function |
GPD2 enables tyrosine phosphorylation during sperm capacitation. GPD2 activity is required for reactive oxygen species generation in mouse spermatozoa during capacitation |
713077 |
| 1.1.5.3 | physiological function |
isoform mtG3PDH is essential for the bloodstream stage of Trypanosoma brucei, while in the procyclic stage the enzyme is dispensable |
-, 740404 |
| 1.1.5.3 | physiological function |
mGPDH overexpression enhances the wound healing ability in prostate cancer cells |
760855 |
| 1.1.5.3 | physiological function |
mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) is a ubiquinone-linked enzyme in the mitochondrial inner membrane best characterized as part of the glycerol phosphate shuttle that transfers reducing equivalents from cytosolic NADH into the mitochondrial electron transport chain |
-, 741302 |
| 1.1.5.3 | physiological function |
the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane |
763434 |
| 1.1.5.3 | physiological function |
the enzyme is involved in glycolysis, electron transport, glycerophospholipids metabolism, and hyperosmotic stress response |
-, 740482 |
| 1.1.5.3 | physiological function |
the enzyme plays a central role in glycerolipid metabolism and stress response. It increases salt and osmotic stress resistance by modulating redox state and respiration |
762941 |
