EC Number |
General Information |
Reference |
---|
1.1.1.38 | malfunction |
enzyme inactivation improves the anaerobic production of four-carbon dicarboxylic acids by recombinant Escherichia coli strains expressing oxaloacetate-forming pyruvate carboxylase |
760378 |
1.1.1.38 | malfunction |
knockdown of isoform Me2 markedly reduces the glycolytic flux and impairs osteoblast proliferation and differentiation |
760840 |
1.1.1.38 | malfunction |
knockdown of ME2 does not inhibit insulin release stimulated by glucose, pyruvate or 2-aminobicyclo [2,2,1]heptane-2-carboxylic acid-plus-glutamine |
741010 |
1.1.1.38 | metabolism |
isoform Me2 funnels glucose carbons into malate-aspartate shuttle to sustain glycolysis |
760840 |
1.1.1.38 | more |
the molecular basis for the different allosteric properties and quaternary structural stability of m-NAD(P)-ME, EC 1.1.1.38 and c-NADP-ME, EC 1.1.1.40. The structural features near the fumarate binding site and the dimer interface are highly related to the quaternary structural stability of c-NADP-ME and m-NAD(P)-ME. Lys57 plays functional roles in both the allosteric regulation and the subunit-subunit interaction of humanm-NAD(P)-ME |
737754 |
1.1.1.38 | physiological function |
the mitochondrial malic enzyme isoform Me2 functionally couples the mitochondria with aerobic glycolysis in osteoblasts |
760840 |