EC Number   |
General Information |
Reference |
|---|
   1.1.1.361 | evolution |
the requirement for the alpha-anomer as substrate indicates that NtdC and NtdA, the subsequent enzyme in the pathway, have co-evolved to recognize the alpha-anomer in order to avoid mutarotation between enzymatic steps |
-, 762545 |
| 1.1.1.361 | metabolism |
glucose-6-phosphate 3-dehydrogenase (NtdC) catalyzes the oxidation of glucose 6-phosphate by NtdC is the first step in kanosamine biosynthesis |
-, 762724 |
| 1.1.1.361 | metabolism |
NtdC is an NAD-dependent dehydrogenase that catalyzes the conversion of glucose 6-phosphate (G6P) to 3-oxoglucose 6-phosphate, the first step in kanosamine biosynthesis in Bacillus subtilis and other closely-related bacteria. Kanosamine biosynthesis in Bacillus subtilis, overview |
-, 762545 |
| 1.1.1.361 | metabolism |
the enzyme catalyzes the first step in kanosamine biosynthesis |
762724 |
| 1.1.1.361 | physiological function |
glucose-6-phosphate 3-dehydrogenase (NtdC) is an NAD-dependent oxidoreductase encoded in the NTD operon of Bacillus subtilis |
-, 762724 |
| 1.1.1.361 | physiological function |
the ntd operon is essential for biosynthesis of the unusual disaccharide 3,3'-neotrehalosadiamine. The enzymes catalyze the biosynthesis of kanosamine from D-glucose 6-phosphate. NtdC is a D-glucose-6-phosphate-3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase, and NtdB is a kanosamine-6-phosphate phosphatase |
725212 |
