EC Number   |
General Information |
Reference |
|---|
   1.1.1.30 | malfunction |
enzyme inactivation in developing zebrafish embryo results in heme deficiency and delays erythrocyte maturation |
739558 |
| 1.1.1.30 | malfunction |
inhibiting expression of the 3-hydroxybutyrate dehydrogenase-2 gene results in abnormal accumulation of intracellular iron, increased oxidative stress, and mitochondrial iron deficiency |
738207 |
| 1.1.1.30 | metabolism |
steady-state ordered kinetic mechanism for acetoacetate reduction, where hydride transfer is not rate limiting. Hydride transfer becomes more rate limiting with non-native substrate 3-oxovalerate. Hydride and proton transfers occur in the same transition state. Transition states show concerted, albeit not synchronous, proton and hydride transfers to 3-oxovalerate |
-, 760246 |
| 1.1.1.30 | metabolism |
steady-state ordered kinetic mechanism for acetoacetate reduction, where hydride transfer is not rate limiting. Hydride transfer becomes more rate limiting with non-native substrate 3-oxovalerate. Hydride and proton transfers occur in the same transition state. Transition states showconcerted, albeit not synchronous, proton and hydride transfers to 3-oxovalerate |
760246 |
| 1.1.1.30 | more |
Gln94, His144, Lys152, and Gln196 form hydrogen bonds with carboxyl and/or ketone group of acetoacetate, Trp187, Trp257 form hydrophobic interactions with the carbon atoms of acetoacetate, and Ser142 and Tyr155 are directly related to the catalytic mechanism |
721853 |
